Substituted phenyloxazolidinones and their use as antibiotics

US6495551B1 · kind B1 · utility

Inventors

• Michael John Betts · Macclesfield, GB
• Michael Lingard Swain · Stockport, GB

Key dates

• Filing date: May 25, 2000
• Grant date: Dec 17, 2002
• Expiry date: May 25, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention concerns compounds of formula (I), wherein, for example,R1 is of the formula —NHC(═O)Ra wherein Ra is (1-4C)alkyl;R2 and R3 are independently hydrogen or fluoro;R5 and R6 are, for example, hydrogen;R4 is —X—Y—Het.;wherein, for example,X is a direct bond and Y is —(CH2)m— or —CONH—(CH2)m—;or X is —(CH2)n— and Y is —S(O)p—(CH2)m—;or X is —CH2O—or —CH2NH— and Y is —CO—(CH2)m—;wherein n is 1, 2 or 3; m is 0, 1, 2 or 3 and p is 0, 1 or 2;wherein Het. is a heterocyclic ring, unsaturated or saturated, optionally substituted by, for example, (1-4C)alkyl, halo, cyano, nitro or amino; pharmaceutically acceptable salts and in vivo hydrolysable ester thereof; processes for their preparation; pharmaceutical compositions containing them and their use as antibacterial agents.