Methods and compositions for overcoming resistance to biologic and chemotherapy
US6495553B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 7, 1998 |
| Grant date | Dec 17, 2002 |
| Priority date | — |
| Expiry date | Aug 7, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/91011
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides a method for identifying potential therapeutic agents by contacting a target cell with a candidate therapeutic agent which is a selective substrate for an endogenous, intracellular enzyme in the cell which is enhanced in its expression as a result of selection by biologic or chemotherapy. This invention also provides methods and examples of molecules for selectively killing a pathological cell by contacting the cell with a prodrug that is a selective substrate for an endogenous, intracellular enzyme. The prodrug is subsequently converted to a cellular toxin. Further provided by this invention is a method for treating a pathology characterized by pathological, hyperproliferative cells in a subject by administering to the subject a prodrug that is a selective substrate for an endogenous, overexpressed, intracellular enzyme, and converted by the enzyme to a cellular toxin in the hyperproliferative cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.