&bgr;-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-&agr;

US6495565B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Pharma Company · US

Inventors

• Jingwu Duan · Yardley, US
• Bryan Wayne King · Blue Bell, US
• Carl P. Decicco · New Hope, US
• Thomas P. Maduskuie, Jr. · Wilmington, US
• Matthew E. Voss · Singapore, SG

Key dates

• Filing date: Mar 16, 2001
• Grant date: Dec 17, 2002
• Expiry date: Mar 16, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application describes novel &bgr;-amino acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, Ua, Xa, Ya, Za, R1, R2, R3, R4, and R4a are defined in the present specification, which are useful as metalloprotease and/or as TNF-&agr; inhibitors.