Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
US6495589B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 12, 2000 |
| Grant date | Dec 17, 2002 |
| Priority date | — |
| Expiry date | Dec 12, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds according formula (I)A—G—Z—W and pharmaceutically acceptable salts, solvates or hydrates thereof; wherein,A is (C6-C10)aryl, (C6-C10)aryl-SO2, (C6-C10)aryl-CH2—, (C6-C10)arylcarbonyl, (C1-C9)heteroaryl, (C1-C9)heteroaryl-SO2—, (C1-C9)heteroaryl-CH2—; or (C1-C9)heteroarylcarbonyl;G is selected from the group consisting of:  where B is (C6-C10)aryl or (C1-C9)heteroaryl, and X is CH2, SO2, or carbonyl;  where X is CH2, SO2, or carbonyl; and R1 and R1′ are each independently selected from H, CN, (C1-C8)alkyl-, and phenyl(CH2)—, wherein said alkyl and phenyl groups are optionally substituted; and  where Z and W are as defined in the present Specificiation; and pharmaceutical compositions and methods useful to increase secretion of growth hormone(GH) from the anterior pituitary of mammals, including on a sustained release basis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.