Fungal efflux pump inhibitors
US6495591B1 · kind B1 · utility
0Cited by
16References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 1, 1998 |
| Grant date | Dec 17, 2002 |
| Priority date | — |
| Expiry date | Oct 1, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/365
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The use of compounds of the milbemycin class as inhibitors of efflux pumps in microbes or other cells is described, along with pharmaceutical compositions incorporating a milbemycin. Also described is a method of screening for compounds which inhibit a CDR1, CDR2, BEN, or FLU1 efflux pump or a pump with components having a high level of protein level sequence similarity with the components of those efflux pumps.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.