Methods for extracting substances using alternating current
US6496728B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 13, 2001 |
| Grant date | Dec 17, 2002 |
| Priority date | — |
| Expiry date | Apr 20, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/0448
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A variety of methods for extracting different substances such as endogenous substances, pharmaceutical substances, markers of disease, and their metabolites across a tissue are provided. The methods utilize an AC signal to maintain a substantially constant electrical state in a region of the tissue through which extraction occurs, thereby allowing substances to be transported across the tissue in a controlled and predictable manner. Certain methods include an optional AC or DC prepulse signal to initially achieve the target electrical state. An optional DC offset signal can also be utilized to assist in promoting extraction of the substance. The methods have utility in a variety of different clinical settings and applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.