Intrinsic dissolution apparatus with stationary sample holder
US6497157B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 13, 2000 |
| Grant date | Dec 24, 2002 |
| Priority date | — |
| Expiry date | Apr 2, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2013/006
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
For intrinsic dissolution testing, a drug pellet (i.e., the dissolution test sample) is retained within a cylindrical recess in a sample holder that is placed at the bottom of a dissolution vessel containing an appropriate dissolution medium with the sample holder oriented with the drug pellet facing up. During the testing cycle, the dissolution medium may be stirred, e.g., using a conventional USP 2 rotating paddle, while the sample holder (and drug pellet) remain stationary at the bottom of the vessel. The orientation of the drug pellet during testing (i.e., facing up) decreases the likelihood of retention of air bubbles formed at the surface of the drug pellet (which bubbles could otherwise decrease the effective dissolution rate), thereby providing more accurate and consistent intrinsic dissolution test results.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.