Method for measuring the association of substructures of pathological protein depositions

US6498017B2 · kind B2 · utility

Assignee

• EVOTEC BIOSYSTEMS GMBH · DE

Inventors

• Detlev Riesner · Düsseldorf, DE
• Karin Post · Goldkronach, DE
• Oliver Schaefer · Sankt Wendel, DE
• Martin Pitschke · Velbert, DE
• Manfred Eigen · Göttingen, DE
• Jan Bieschke · Oettingen, DE

Key dates

• Filing date: May 22, 2000
• Grant date: Dec 24, 2002
• Expiry date: Jun 8, 2020

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/6896
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for the diagnostic detection of diseases associated with protein depositions (pathological protein depositions) by measuring an association of substructures of the pathological protein depositions, structures forming pathological protein depositions, structures corresponding to pathological protein depositions and/or pathological protein depositions as a probe;to substructures of the pathological protein depositions structures forming pathological protein depositions, structures corresponding to pathological protein deposition and/or pathological protein depositions as targets;characterized in that the target is detected in liquid phase wherein, in the case of detecting Alzheimer's disease, the liquid phase is obtained from body fluids or is itself a body fluid;with the proviso that the association of the probe to the target is measured before self-aggregation of the probe predominates.