Targeted delivery through a cationic amino acid transporter
US6498027B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 20, 1999 |
| Grant date | Dec 24, 2002 |
| Priority date | — |
| Expiry date | May 20, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/859
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the targeted delivery of substances to cells. The invention provides a virus-like particle or gene delivery vehicle provided with a ligand capable of binding to a human amino acid transporter. Provided are, for example, ligands that can bind to the human transporter of cationic L-amino acids (hCAT1). Such hCAT1 binding molecules find applications in the design of vector systems for entry into human or primate cells. Preferred are retroviral envelope molecules, which—when incorporated in a virus particle—can infect hCAT1 positive cells at high frequencies. Also disclosed are methods for the design of such hCAT1 binding molecules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.