Morphogen treatment for chronic renal failure
US6498142B1 · kind B1 · utility
35Cited by
4References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 6, 1996 |
| Grant date | Dec 24, 2002 |
| Priority date | — |
| Expiry date | May 6, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P13/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects at risk chronic renal failure, or at risk of a need for renal replacement therapy. The methods involve the administration of certain morphogens, inducers of those morphogens, or agonists of the corresponding morphogen receptors, or implantation of renal cells induced with those morphogens. The morphogens useful in the invention include osteogenic protein-1 (OP-1) and other members of the OP-1 subfamily of the TGF-&bgr; superfamily of growth factors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.