Pyrido[2,3-D]pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation
US6498163B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 2, 1999 |
| Grant date | Dec 24, 2002 |
| Priority date | — |
| Expiry date | Aug 2, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides pyridopyrimidines and 4-aminopyrimidines that are useful for treating cell proliferative disorders, such as cancer and restenosis. We have now discovered a group of 7,8-dihydro-2-(amino and thio)pyrido[2,3-d]pyrimidines and 2,4-diaminopyrimidines that are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases. The compounds are readily synthesized and can be administered by a variety of routes, including orally, and have sufficient bioavailability. This invention provides compounds of Formula I: and Formula II: whereW is NH, S, SO, or SO2,R1 includes phenyl and substituted phenyl,R2 includes alkyl and cycloalkyl,R3 includes alkyl and hydrogen,R8 and R9 include hydrogen and alkyl, andZ is carboxy.This invention also provides pharmaceutical formulations comprising a compound of Formula I or II together with a pharmaceutically acceptable carrier, diluent, or excipient therefor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.