Excitatory amino acid receptor modulators

US6498180B1 · kind B1 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Ivan Collado Cano · Madrid, ES
• Concepcion Pedregal Tercero · Madrid, ES
• Alicia Marcos Llorente · Las Rozas, ES
• Beatriz Lopez de Uralde Garmendia · Alcobendas, ES
• Maria Rosario Gonzalez Garcia · Madrid, ES
• Ana Belen Bueno Melendo · Alcobendas, ES

Key dates

• Filing date: Nov 16, 2001
• Grant date: Dec 24, 2002
• Expiry date: Nov 16, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I) in which R1 is halo-C1-10 alkyl; halo-C2-10 alkenyl; or (CH2)nY in which n is 1 or 2 and Y is OH, CN, N3, OR3, SH, S(O)pR4, S(O)3H, NH2, NHR5, NR6R7, NHCOR8, NO2, CO2H, CONHR9, 1H-tetrazol-5-yl, 5-phenyltetrazol-2-yl or PO3H2; R3, R5, R6, R7, R8 and R9 are each selected independently from C1-4 alkyl, aryl and aryl-C1-4 alkyl; R4 is selected from C1-4 alkyl, aryl, aryl-C1-4 alkyl, and 1H-tetrazol-5-yl, carboxy-(1-4C)alkyl and 1H-tetrazol-5-yl-C1-4 alkyl; and p is 0, 1, 2 or 3; or a salt or ester thereof, provided that R1 is not methoxymethyl, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.