Phosphinite-oxazolines and metal complexes thereof

US6498256B2 · kind B2 · utility

Assignee

• SOLVIAS AG · CH

Inventors

• Andreas Pfaltz · Binningen, CH
• Joerg R. Blankenstein · Pulheim, DE
• Frederik Menges · Schriesheim, DE

Key dates

• Filing date: Sep 20, 2001
• Grant date: Dec 24, 2002
• Expiry date: Sep 20, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F15/0033
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formulae I and Ia, whereinX1 is secondary phosphino; R3 is hydrogen, a hydrocarbon radical having from 1 to 20 carbon atoms, a heterohydrocarbon radical, bonded via a carbon atom, having from 2 to 20 atoms and at least one hetero atom selected from the group O, S and NR, or ferrocenyl; R is H or C1-C4alkyl; each R4 individually or both R4 together are a hydrocarbon radical having from 1 to 20 carbon atoms; and R01 and R02 are each independently of the other a hydrogen atom or a hydrocarbon radical having from 1 to 20 carbon atoms, are chiral ligands for metal complexes with metals of sub-groups I and VII, which are catalysts for asymmetric addition reactions, for example of hydrogen, to prochiral unsaturated organic compounds.