2,3-olefinic epothilone derivatives

US6498257B1 · kind B1 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Gregory D. Vite · Titusville, US
• Robert M. Borzilleri · Haneys Mill, US
• Gerhard Hofle · Braunschweig, DE
• Thomas Leibold · Braunschweig, DE

Key dates

• Filing date: Mar 29, 1999
• Grant date: Dec 24, 2002
• Expiry date: Mar 29, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to 2,3-position modified epothilone derivatives, methods of preparation of the derivatives, and intermediates therefor. The compounds of the invention as 16-membered macrolides having the general structure, which have microtubule-stabilizing effects and cytotoxic activity against rapidly proliferating cells, such as, tumor cells or other hyperproliferative cellular disease.