Particulate formulations

US6500461B2 · kind B2 · utility

Assignee

• The Liposome Company, Inc. · US

Inventors

• Walter Perkins · Ewing Township, US
• Xingong Li · Cranbury, US
• Donald Hirsh · Trenton, US
• Eric Mayhew · Monmouth Junction, US
• Imran Ahmad · Wadsworth, US
• Shaukat Ali · Monmouth Junction, US
• Andrew S. Janoff · Yardley, US

Key dates

• Filing date: May 19, 1999
• Grant date: Dec 31, 2002
• Expiry date: May 19, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/542
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides vehicles capable of delivering high concentrations of poorly hydrophilic/poorly lipophilic compounds to animals, by combining compounds having biocompatible hydrophobic domains with conjugates having both hydrophobic and hydrophilic regions. Such formulations are suitable for a number of uses in animals, particularly the administration thereto of high concentrations of therapeutically useful compound, without an undue level of side effects.