Kainate-binding, human CNS receptors of the EAA3 family
US6500624B1 · kind B1 · utility
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12Claims
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Key dates
| Filing date | Feb 1, 1994 |
| Grant date | Dec 31, 2002 |
| Priority date | — |
| Expiry date | Feb 1, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/70571
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of the kainate-binding type of EAA receptor, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.
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