Patent · US Expired

Method for detecting oxidized forms of soluble guanylate cyclase

US6500631B1 · kind B1 · utility

7Cited by

2References

12Claims

0Family size

Assignee

Aventis Pharma Deutschland GmbH · DE

Inventors

Ursula Schindler · Bad Soden, DE
Hartmut Strobel · Liederbach, DE
Peter Schindler · Rodgau, DE
Alexander Muelsch · Heidelberg, DE

Key dates

Filing date	Sep 14, 2000
Grant date	Dec 31, 2002
Priority date	—
Expiry date	Sep 14, 2020

Classification

Technology area (CPC G)Physics
CPC primaryG01N2500/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase when the heme iron of at least part of this soluble guanylate cyclase is oxidized to the trivalent state and also to diagnostic aids or kits for detecting a soluble guanylate cyclase with trivalent heme iron. Further, the invention relates methods for detecting a soluble guanylate cyclase lacking a heme group, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase lacking a heme group.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.