Naphthalenecarboxamides as tachykinin receptor antagonists

US6500818B1 · kind B1 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Peter Bernstein · Wallingford, US
• Robert Dedinas · Newark, US
• Cyrus J. Ohnmacht · Wilmington, US
• Keith Russell · Wilmington, US

Key dates

• Filing date: Mar 30, 2001
• Grant date: Dec 31, 2002
• Expiry date: Mar 30, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having the following formula wherein L, M, R2, R3, R4, R5, R6, R7, X1 and X2 are as defined in the specification, pharmaceutically-acceptable salt thereof, useful for treating depression, anxiety, asthma, rheumatoid arthritis, Alzheimer's disease, cancer, schizophrenia, oedema, allergic rhinitis, inflammation, pain, gastrointestinal-hypermotility, emesis, Huntington's disease, psychoses, hypertension, migraine, bladder hypermotility, or urticaria, compositions including such compounds and processes for making such compounds.