Inhibitors of rotamase enzyme activity

US6500843B2 · kind B2 · utility

Assignees

• GPI Nil Holdings Inc. · US
• The Johns Hopkins University School of Medicine · US

Inventors

• Joseph P. Steiner · Hampstead, US
• Solomon H. Snyder · Baltimore, US
• Gregory S. Hamilton · Catonsville, US
• Ted M. Dawson · Baltimore, US

Key dates

• Filing date: Nov 5, 1999
• Grant date: Dec 31, 2002
• Expiry date: Nov 5, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.