Antithrombotic agents

US6500851B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Douglas Wade Beight · Frankfort, US
• Trelia Joyce Craft · Indianapolis, US
• Jeffry Bernard Franciskovich · Zionsville, US
• Theodore Goodson, Jr. · Indianapolis, US
• Steven E. Hall · Ewing Township, US
• David Kent Herron · Indianapolis, US
• Valentine Joseph Klimkowski · Carmel, US
• Jeffrey Alan Kyle · Fishers, US
• John Joseph Masters · Fishers, US
• David Mendel · Indianapolis, US
• Guy Milot · Chapel Hill, US
• Jason Scott Sawyer · Indianapolis, US
• Robert T. Shuman · Greenwood, US
• Gerald Floyd Smith · Indianapolis, US
• Anne Louise Tebbe · Hamburg, DE
• Jennifer Marie Tinsley · Ypsilanti, US
• Leonard Crayton Weir · Westfield, US
• James H. Wikel · Greenwood, US
• Michael Robert Wiley · Zionsville, US
• Ying Kwong Yee · Kennett Square, US

Key dates

• Filing date: Feb 22, 2002
• Grant date: Dec 31, 2002
• Expiry date: Feb 26, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.