Hemoglobin-polysaccharide conjugates
US6500930B2 · kind B2 · utility
49Cited by
9References
29Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 26, 1999 |
| Grant date | Dec 31, 2002 |
| Priority date | — |
| Expiry date | Mar 26, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0026
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Hemoglobin conjugates useful as a hemoglobin-based oxygen carriers are prepared by reacting hemoglobin with oxidatively ring-opened polysaccharides such as hydroxyethyl starch or dextran, and storing the resultant conjugate under conditions which allow it to transform to a lower molecular weight product, after conjugation. The conjugate is then reductively stabilized to form secondary amino bonds between the hemoglobin and the polysaccharide, and formulated as an BOC.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.