Lifeguard (LFG) polynucleotides and polypeptides and methods of use thereof
US6500940B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 9, 1999 |
| Grant date | Dec 31, 2002 |
| Priority date | — |
| Expiry date | Jun 9, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02E50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A substantially purified lifeguard (LFG) polypeptide is provided. The polypeptide includes an amino acid sequence as set forth in SEQ ID NO:2, or a conservative variant thereof. An isolated polynucleotide is provided that encodes an amino acid sequence as set forth in SEQ ID NO:2, or a conservative variant thereof. An antibody is provided that binds to a polypeptide having an amino acid sequence as set forth in SEQ ID NO:2. A method is provided for identifying a compound which affects a function a polypeptide as set forth in SEQ ID NO:2, or a conservative variant thereof, or affects the expression of a polynucleotide comprising a sequence as set forth in SEQ ID NO:1. A method is provided for treating a subject with a disorder associated with decreased or increased Fas-mediated cell death. A method is provided for treating a patient having or at risk of having a disorder associated with increased Fas-mediated cell death.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.