Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
US6503184B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 23, 2000 |
| Grant date | Jan 7, 2003 |
| Priority date | — |
| Expiry date | Feb 23, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding human TR11, TR11SV1, and TR11SV2 receptors. TR11, TR11SV1, and TR11SV2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR11, TR11SV1, and TR11SV2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR11, TR11SV1, and TR11SV2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR11, TR11SV1, and TR11SV2 receptors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.