Oxygen activatable formulations for disinfection or sterilization
US6503507B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Mar 6, 2000 |
| Grant date | Jan 7, 2003 |
| Priority date | — |
| Expiry date | Mar 6, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/404
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are disclosed for producing air-activated, i.e., oxygen (O2) activated, disinfectant-sterilent solutions. Solutions containing a haloperoxidase (i.e., a halide:hydrogen peroxide (H2O2) oxidoreductase, such as myeloperoxidase, eosinophil peroxidase or lactoperoxidase) plus a halide or combination of halides (i.e., chloride, bromide and/or iodide), an oxidase (i.e., a substrate:O2 oxidoreductase) capable of generating H2O2, and a substrate specific for that oxidase, are separately prepared under aerobic conditions, but all of the component solutions are made anaerobic prior to final combination and mixing. The anaerobic formulations are dispensed into containers capable of maintaining the anaerobic condition (e.g., pressurized canisters). Dispensing the solution at the time of use exposes the formulation to air (i.e., O2) which activates its disinfectant-sterilent properties. O2 is the rate limiting component for oxidase generation of H2O2. Under aerobic conditions the oxidase catalyzes the oxidation of its substrate and the reduction of O2 to generate H2O2. In turn, H2O2 serves as substrate for haloperoxidase which catalyzes the oxidation of halide to hypoha…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.