Hydroxyalkanoylaminolactams and related structures as inhibitors of a &bgr; protein production
US6503902B2 · kind B2 · utility
18Cited by
25References
47Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 14, 2001 |
| Grant date | Jan 7, 2003 |
| Priority date | — |
| Expiry date | Mar 14, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A&bgr;-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to &bgr;-amyloid production such as Alzheimer's disease and Down's Syndrome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.