Biocompatible carrier containing actinomycin D and a method of forming the same
US6503954B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 21, 2000 |
| Grant date | Jan 7, 2003 |
| Priority date | — |
| Expiry date | Jul 21, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/608
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A biocompatible carrier and a composition for forming the carrier are disclosed. The carrier is made from an ethylene vinyl alcohol copolymer which can serve as a reservoir, allowing for the local delivery and sustained release of actinomycin D. The carrier can be formed from the ethylene vinyl alcohol, copolymer, a dimethylsulfoxide solvent, and actinomycin D. Alternatively, the carrier can be formed from an ethylene vinyl alcohol copolymer, a dimethylsulfoxide solvent, actinornycin D, and a wetting fluid. The carrier can serve as a coating for a prosthesis, for example a stent. The composition is applied to a surface of the prosthesis and essentially all of the dimethylsulfoxide solvent or dimethylsulfoxide solvent/wetting fluid is removed or allowed to evaporate to form the coating.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.