Very large scale immobilized polymer synthesis

US6506558B1 · kind B1 · utility

Assignee

• AFFYMETRIX, INC. · US

Inventors

• Stephen P. A. Fodor · Palo Alto, US
• Lubert Stryer · Stanford, US
• Michael C. Pirrung · Durham, US
• J. Leighton Read · Palo Alto, US
• Paul D. Hoeprich, Jr. · Pleasanton, US

Key dates

• Filing date: Nov 29, 1995
• Grant date: Jan 14, 2003
• Expiry date: Nov 29, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.