Patent · US Expired

Splice variants for human 5-HT4 serotonin receptor and their applications, in particular for screening

US6506580B1 · kind B1 · utility

0Cited by

2References

6Claims

0Family size

Assignee

Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventors

Rodolphe Fischmeister · Orsay, FR
Michel Langlois · Buc, FR
Yamina Dahmoune · Joinville-le-Pont, FR
Monique Gastineau · Wissous, FR
Olivier Blondel · Washington, US
Johan Hoebeke · Kessel-Lo, BE

Key dates

Filing date	Sep 19, 2000
Grant date	Jan 14, 2003
Priority date	—
Expiry date	Sep 19, 2020

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention concerns an isolated polypeptide constitutive of splice variants for human serotonin receptor whereof the amino acid sequence is selected among the sequence SEQ ID No. 2 of the 5-HT4(c) polypeptide variant or the sequence SEQ ID No. 4 of the 5-HT4(d) polypeptide variant, or any polypeptide fragment or biologically active derivative thereof. The invention also concerns the inverse agonist effect of ML 10375 on 5-HT4(c) and 5-HT4(d) receptors.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.