Nasal transmucosal delivery of peptide conjugated with biocompatible polymers
US6506730B1 · kind B1 · utility
Inventors
Key dates
| Filing date | Aug 15, 2000 |
| Grant date | Jan 14, 2003 |
| Priority date | — |
| Expiry date | Aug 15, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a pharmaceutical composition for the nasal transmucosal delivery of a biocompatible polymer-biologically active peptide conjugate. The pharmaceutical composition of the present invention increases the water solubility of peptide, which is sparingly soluble in water, improves its stability by protecting it from being degraded by proteases. As a result, the number of administrations of the drug and the side-effects induced by drug abuse are decreased. In addition, since the pharmaceutical composition of the present invention is delivered through the nasal cavity, it allows drug activity to be expressed in a short period of time and improves a bioavailability.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.