Patent · US Expired

20(S) camptothecin glycoconjugates

US6506734B1 · kind B1 · utility

5Cited by

7References

12Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Hans-Georg Lerchen · Leverkusen, DE
Karsten von dem Bruch · Leverkusen, DE
Jorg Baumgarten · Wuppertal, DE
Michael Sperzel · Wuppertal, DE

Key dates

Filing date	Oct 27, 1999
Grant date	Jan 14, 2003
Priority date	—
Expiry date	Oct 27, 2019

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to glycoconjugates of 20(S)-camptothecin, in which a 3-O-methylated &bgr;-L-fucose unit is linked to the 20-hydroxyl group of a camptothecin derivative via a thiourea-modified peptide spacer. The invention furthermore relates to processes for the preparation of the compounds according to the invention and to their use as medicaments, in particular in connection with oncoses.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.