Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents

US6506739B1 · kind B1 · utility

Assignee

• Telik, Inc. · US

Inventors

• R. Jason Herr · Voorheesville, US
• Robert T. Lum · Palo Alto, US
• Steven R. Schow · Washingtonville, US
• Fanying Meng · South San Francisco, US
• Michael R. Kozlowski · Palo Alto, US
• Pavel E. Zhichkin · Latham, US

Key dates

• Filing date: May 1, 2001
• Grant date: Jan 14, 2003
• Expiry date: May 1, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/2458
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Bis-(N,N′-bis-(2-haloethyl)amino)phosphoramidates, pharmaceutical compositions containing them, methods of treatment using them, and processes for their preparation. The compounds possess anti-tumor activities or are capable of being modified to have anti-tumor activities; and this invention relates to the use of the compounds in methods for the treatment of tumors and, especially, for the treatment of cancer.