Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents

US6506747B1 · kind B1 · utility

Assignee

• Boehringer Ingelheim Pharmaceuticals, Inc. · US

Inventors

• Rajashekhar Betageri · Bethel, US
• Charles Cywin · Bethel, US
• Karl D. Hargrave · Brookfield, US
• Mary Ann Hoermann · Holmes, US
• Thomas Martin Kirrane, Jr. · Danbury, US
• Thomas M. Parks · San Mateo, US
• Usha R. Patel · Brookfield, US
• John Proudfoot · Newtown, US
• Rajiv Sharma · Mumbai, IN
• Sanxing Sun · Danbury, US
• Xiao-Jun Wang · Danbury, US

Key dates

• Filing date: Jun 3, 1999
• Grant date: Jan 14, 2003
• Expiry date: Jun 3, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

1-(4-aminophenyl)pyrazoles optionally substituted on the 3- and 5-positions of the pyrazole ring and on the amino group at the 4-position of the phenyl ring are disclosed and described, which pyrazoles inhibit IL-2 production in T-lymphocytes.