Methods of making and using N-desmethylzopiclone

US6506753B2 · kind B2 · utility

Assignee

• Sepracor, Inc. · US

Inventors

• Thomas Jerussi · Framingham, US
• Chrisantha H. Senanayake · Shrewsbury, US
• Paul Rubin · Sudbury, US
• Yaping Hong · Framingham, US
• Roger Bakale · Shrewsbury, US
• Tingjian Xiang · Thousand Oaks, US
• Fran McConville · Grafton, US

Key dates

• Filing date: Jun 11, 2001
• Grant date: Jan 14, 2003
• Expiry date: Jun 11, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone.