Certain alkylene diamine-substituted heterocycles
US6506762B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 29, 2000 |
| Grant date | Jan 14, 2003 |
| Priority date | — |
| Expiry date | Sep 29, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/70571
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention also provides a general method to whereby mono-, bi-, or tricyclic heterocycles may be modified to obtain potent antagonists at the NPY1 receptor.The present invention provides novel, potent, non-peptidic antagonists of NPY receptors, particularly, the NPY1 receptors, designed from a selection of mono-, bi-, or tri-cyclic heterocyclic cores.This invention relates to novel compounds, compositions, and methods for the treatment of physiological disorders associated with an excess of neuropeptide Y. The novel compounds encompassed by the present invention are those of the formula I-XV. whereinX is N or CR14; W is S, O, or NR15; Y is N or CR3; E, F, and G are each, independently, CR3 or N; I and J are each, independently, C═O, S, O, CR3R16 or NR15 when single bonded to both adjacent ring atoms, or N, or CR3 when double bonded to an adjacent ring atom;K is N or CR3 when double bonded to L or J, or O, S, C═O, CR3R16, or NR15 when single bonded to both adjacent ring atoms, or N or CR3 when double bonded to an adjacent ring atom;L is N or CR16 when single bonded to all atoms to which it is attached, or C (carbon) when double bonded to K;the 6- or 7-membered …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.