Pyrano [3,2-d]-1,3-dioxin-8 ones
US6506911B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 4, 2001 |
| Grant date | Jan 14, 2003 |
| Priority date | — |
| Expiry date | Sep 4, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel 3-hydroxypyridin-4-one compound of formula I is provided whereinR is hydrogen or a group that is removed by metabolism in vivo to provide the free hydroxy compound,R1 is an aliphatic hydrocarbon group or an aliphatic hydrocarbon group substituted by a hydroxy group or a carboxylic acid ester, sulpho acid ester or a C1-6 alkoxy, C6-aryloxy or C7-10aralkoxy ether thereof,R3 is selected from hydrogen and C1-6 alkyl;and R4 is selected from hydrogen, C1-6 alkyl and a group as described for R2;characterised in thatR2 is selected from groups(i) —CONH—R5 (ii) —CH2NHCO—R5 (iii) —SO2NH—R5 (iv) —CH2NHSO2—R5 (v) —CR6R6OR7 (viii) —CONHCOR5  whereinR5 is selected from hydrogen and optionally hydroxy, alkoxy, or aralkoxy substituted C1-3 alkyl, aryl and C7-13 aralkyl,R6 is independently selected from hydrogen, C1-13 alkyl, aryl and C7-13 aralkyl,and R7 is selected from hydrogen, C1-13 alkyl, aryl and C7-13 aralkyl or a pharmaceutically acceptable salt of any such compoundwith the proviso that when R7 is hydrogen, R6 is not selected from aryl and with the proviso that the compound is not l-ethyl-2-(1′hydroxyethyl)-3-hy…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.