Process to manufacture simvastatin and intermediates
US6506929B1 · kind B1 · utility
2Cited by
9References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 24, 2001 |
| Grant date | Jan 14, 2003 |
| Priority date | — |
| Expiry date | Apr 24, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D309/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2′-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.