Substituted benzenesulfonylureas and -thioureas-processes for their preparation and their use as pharmaceuticals

US6506937B2 · kind B2 · utility

Inventors

• Heinrich Englert · Hofheim, DE
• Dieter Mania · Königstein, DE
• Jens Hartung · Rodgau, DE
• Heinz Gogelein · Frankfurt am Main, DE
• Joachim Kaiser · Frankfurt am Main, DE
• Wolfgang Linz · Mainz, DE
• David G. Wettlaufer · Phillipsburg, US

Key dates

• Filing date: Nov 29, 2001
• Grant date: Jan 14, 2003
• Expiry date: Dec 10, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C335/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Benzenesulfonylureas and -thioureas of the formula I where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro) (mercapto)alk(oxy)yl, E is O or S; Y is —[CR(3)2]n—, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO3 or alk(yl)oxy, are described.The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used an antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.