Compositions and methods for recombinant Adeno-Associated Virus production
US6509150B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 5, 1999 |
| Grant date | Jan 21, 2003 |
| Priority date | — |
| Expiry date | Mar 5, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to methods and compositions for the production of recombinant Adeno-Associated Viruses (rAAV). In particular, the invention discloses nucleic acid constructs and packaging cells having improved properties for rAAV production, as well as novel methods of titration and characterization of rAAV preparations. The invention also describes novel sequences which promote or increase the packaging of nucleic acids in rAAV, and their use for producing rAAV with high efficiency. The invention can be used for producing or testing high quality rAAV preparations, for biological, preclinical, clinical or pharmaceutical uses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.