Lactams substituted by cyclic succinates as inhibitors of A&bgr; protein production
US6509333B2 · kind B2 · utility
15Cited by
23References
45Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 1, 2001 |
| Grant date | Jan 21, 2003 |
| Priority date | — |
| Expiry date | Jun 1, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D243/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A&bgr;-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to &bgr;-amyloid production such as Alzheimer's disease and Down's Syndrome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.