2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof

US6509365B1 · kind B1 · utility

Assignee

• BASF SE

Inventors

• Wilfried Lubisch · Mannheim, DE
• Michael Andreas Kock · Schifferstadt, DE
• Thomas Höger · Edingen-Neckarhausen, DE

Key dates

• Filing date: May 17, 2001
• Grant date: Jan 21, 2003
• Expiry date: May 17, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D235/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

2-Phenylbenzimidazoles and 2-phenylindoles of formula I whereinA is N or CH,R1 is hydrogen or alkyl which optionally carries an OR11 group,R11 is hydrogen or alkyl,R2 is hydrogen, chlorine, fluorine, bromine, iodine, alkyl, nitro, CF3, CN, NR21R22, NH—CO—R23, OR21,R21 and R22 are each hydrogen or alkyl,R23 is hydrogen, alkyl or phenyl,R3 is —(CH2)q—NR31R32,q is 0, 1, 2 or 3,R31 is hydrogen, alkyl, (CH2)rNR33R34,R32 is (CH2)rNR33R34,r is 2, 3, 4, 5 or 6,R33 and R34 are each hydrogen, alkyl or phenylalkyl wherein the phenyl ring is optionally substituted, orR33 and R34 and the nitrogen atom form a 3- to 8-membered ring,R4 is hydrogen, alkyl, chlorine, bromine, fluorine, nitro, cyano, NR41R42, NH—CO—R43, OR41,R41 and R42 are each hydrogen or alkyl, andR43 is alkyl or phenyl,are useful as inhibitors of poly(ADP-ribose)polymerase and for the production of drugs.