Transfer hydrogenation process
US6509467B1 · kind B1 · utility
31Cited by
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20Claims
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Key dates
| Filing date | Mar 21, 2001 |
| Grant date | Jan 21, 2003 |
| Priority date | — |
| Expiry date | Mar 21, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D217/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal neutral hydrocarbyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centers. The hydrogen donor is advantageously a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate iminium salts, which are preferably prochiral.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.