Method of lithiating five membered heterocycles

US6509474B1 · kind B1 · utility

Assignee

• CHEMETALL GMBH · DE

Inventors

• Uwe Lischka · Frankfurt am Main, DE
• Dieter Hauk · Friedberg, DE
• Peter Rittmeyer · Pocking, DE
• Ulrich Wietelmann · Friedrichsdorf, DE

Key dates

• Filing date: Jul 20, 2001
• Grant date: Jan 21, 2003
• Expiry date: Jul 20, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a method of lithiating CH-acidic five-membered heterocycles whereby the five-membered heterocycle is reacted with metallic lithium in an ether-containing solvent in the presence of an H acceptor.