Patent · US Expired

Method for the preparation of citalopram

US6509483B2 · kind B2 · utility

4Cited by

20References

9Claims

0Family size

Assignee

H. LUNDBECK A/S · DK

Inventors

Hans Petersen
Haleh Ahmadian · Solrød Strand, DK
Robert Dancer · Copenhagen, DK

Key dates

Filing date	Aug 14, 2001
Grant date	Jan 21, 2003
Priority date	—
Expiry date	Aug 14, 2021

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P25/34
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A method for the preparation of citalopram comprising reacting 5-carboxyphthalide successively with a Grignard reagent of 4-halo-fluorophenyl and a Grignard reagent of 3-halo-N,N-dimethyl-propylamine and then effecting ring closure of the resulting compound of Formula XI to a compound of Formula IV followed by conversion of the compound of Formula IV into citalopram is disclosed. Methods for the manufacture and conversion of the compound of Formula IV are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.