Method of drug delivery to interstitial regions of the myocardium
US6511477B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 28, 1999 |
| Grant date | Jan 28, 2003 |
| Priority date | — |
| Expiry date | Sep 28, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2025/0089
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of treating the heart and other body tissues by injecting a compound comprised of microsphere encapsulated macromolecule therapeutic agents into the myocardium, such that the microsphere size inhibits capillary transport of the compound but may permit lymphatic transport of the compound, and the compound releases therapeutic agents upon degradation of the microsphere. The compounds may be used in a method of treating the coronary arteries in which lymphatic transportable therapeutic agents are injected into the myocardium at a location distal to a target site in the coronary artery, after which they are taken up by the lymphatic vessels and transported proximally relative to the coronary artery, and migrate from the lymphatic vessel to the coronary blood vessel.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.