Tri- and tetra-valent monospecific antigen-binding proteins
US6511663B1 · kind B1 · utility
53Cited by
2References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 18, 2000 |
| Grant date | Jan 28, 2003 |
| Priority date | — |
| Expiry date | Sep 18, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a tri- or tetra-valent monospecific antigen-binding protein comprising three or four Fab fragments bound to each other covalently by a connecting structure, which protein is not a natural immunoglobuline. Further provided are novel connecting structures for use in assembling the proteins of the invention and means for attaching a labeling or effector group thereto. The proteins of the invention are useful, for example, in the treatment and diagnosis of cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.