Methods for designing exogenous regulatory molecules

US6511808B2 · kind B2 · utility

Assignee

• Sangamo Biosciences, Inc. · US

Inventors

• Alan Wolffe · Orinda, US
• Fyodor Urnov · Richmond, US
• Dmitry Guschin · Richmond, US
• Trevor Collingwood · Chesterfield, US
• Xiao-Yong Li · Richmond, US
• Brian H. Johnstone · Fishers, US

Key dates

• Filing date: Apr 27, 2001
• Grant date: Jan 28, 2003
• Expiry date: Apr 27, 2021

Classification

• Technology area (CPC G): Physics
• CPC primary: G16B50/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Methods for the design of exogenous regulatory molecules, comprising a DNA-binding domain and a functional domain, are provided. The methods rely on the identification, isolation and characterization of regulatory DNA sequences obtained on the basis of their accessibility in cellular chromatin.