Modulators of CCR5 chemokine receptor activity

US6511994B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Ronald Kim · Essen, DE
• Jiang Chang · Beijing, CN
• Kevin T. Chapman · Emeryville, US
• Sander G. Mills · Scotch Plains, US

Key dates

• Filing date: Oct 10, 2001
• Grant date: Jan 28, 2003
• Expiry date: Oct 10, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of Formula I: (wherein R1, R2, R3, R4, Q, and X are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor activity. The compounds are useful, for example, in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.