Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2&agr; antagonists
US6511999B2 · kind B2 · utility
20Cited by
7References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 8, 2002 |
| Grant date | Jan 28, 2003 |
| Priority date | — |
| Expiry date | Feb 8, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides novel compounds represented by the general formula I. wherein m, n, X, Y, Z, R, R1 and R2 are as defined in the specification or a pharmaceutically acceptable salt thereof. The novel compounds are PGF2&agr; antagonists, useful in pharmaceutical compositions for treating PGF2&agr;-mediated disease responses such as inflammatory reactions relating to rheumatoid arthritis and psoriasis, reproductive disorders, bronchoconstrictive disorders (asthma), excessive bone breakdown (osteoporosis), peptic ulcers, heart disease, platelet aggregation and thrombosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.