Synthetic spiroketal pyranes as potent anti-cancer agents and use
US6512003B2 · kind B2 · utility
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7References
38Claims
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Key dates
| Filing date | Oct 9, 2001 |
| Grant date | Jan 28, 2003 |
| Priority date | — |
| Expiry date | Oct 9, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/47
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel tubulin binding compounds (SPIKETS) having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The compounds are adapted to interact favorably with a novel SP binding pocket on tubulin, which pocket is useful for screening of anti-tubulin, anti-proliferation, and anti-cancer drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.