Promoters of neural regeneration

US6512004B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Hong-jun Song · Village of La Jolla, US
• Mu-Ming Poo · Village of La Jolla, US
• Guo-li Ming · Village of La Jolla, US
• Marc Tessier-Lavigne · San Mateo, US
• Zhigang He · Wellesley, US

Key dates

• Filing date: Jul 6, 2001
• Grant date: Jan 28, 2003
• Expiry date: Jul 6, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent protein kinase a neural cell subject to growth repulsion mediated by a neural cell growth repulsion factor. The activator may comprise a direct or an indirect activator of the protein kinase; the repulsion factor typically comprises one or more natural, endogenous proteins mediating localized repulsion or inhibition of neural cell growth; and the target cells are generally vertebrate neurons, typically injured mammalian neurons. The subject compositions include mixtures comprising a neural cell, an activator of a cyclic nucleotide dependent protein kinase and a neural cell growth repulsion factor.